Disseminated cryptococcosis in an AIDS patient with unusual clinical presentation.

Disseminated cryptocococcosis is a rare and often fatal disease. Here in we report an unusual fatal case of disseminated cryptococcosis. The patient presented with a past history of postmenopausal bleeding with loss of consciousness, altered mental status, few seizures and a low grade fever. Lumbar puncture revealed elevated pressure, lymphocytic pleocytosis, elevated protein and markedly reduced glucose level. Cryptococcus neoformans was isolated from cerebrospinal fluid and blood. Serological assay revealed the presence of human immunodeficiency virus. The patient was treated with antifungal agents intravenously without any signs of improvement and the patient passed away after two weeks of therapy. This is the first case report of disseminated cryptococcosis in an AIDS patient suffering from cryptoccoccal vaginitis.

Disseminated cryptococcosis in an AIDS patient with unusual clinical presentation

La criptococosis diseminada es una enfermedad poco común y, a menudo,fatal. Los autores presentan el caso de una mujer con esta enfermedad.El historial de la paciente incluía sangrado posmenopáusico, pérdida delconocimiento, alteración de la conciencia, ataques y febrícula. La punciónlumbar reveló presión alta del líquido cefalorraquídeo, pleocitosis linfocitaria,tasas elevadas de proteínas y bajos niveles de glucosa. Cryptococcusneoformans fue aislado en líquido cefalorraquídeo y sangre. Un análisisserológico reveló la presencia del virus de la inmunodeficiencia humana.La paciente fue tratada con agentes antimicóticos por vía intravenosa, sinobservarse mejoría, y falleció tras dos semanas de tratamiento. Este es elprimer caso de criptococosis diseminada en una paciente con sida y vaginitiscriptocócica(AU)

Disseminated cryptocococcosis is a rare and often fatal disease. Here in wereport an unusual fatal case of disseminated cryptococcosis. The patientpresented with a past history of postmenopausal bleeding with loss ofconsciousness, altered mental status, few seizures and a low grade fever.Lumbar puncture revealed elevated pressure, lymphocytic pleocytosis,elevated protein and markedly reduced glucose level. Cryptococcusneoformans was isolated from cerebrospinal fluid and blood. Serological assayrevealed the presence of human immunodeficiency virus. The patient wastreated with antifungal agents intravenously without any signs of improvementand the patient passed away after two weeks of therapy. This is the first casereport of disseminated cryptococcosis in an AIDS patient suffering fromcryptoccoccal vaginitis(AU)